The results show that PE significantly reduced the myocardial infarct size in MIRI animals compared with the control group ( p < 0.001). Then, a total of 20 studies from 17 articles with a total of 355 animals were included in this meta-analysis. They are genistein, quercetin, biochanin A, formononetin, daidzein, kaempferol, icariin, puerarin, rutin, notoginsenoside R1, tanshinone IIA, ginsenoside Rb1, ginsenoside Rb3, ginsenoside Rg1, ginsenoside Re, resveratrol, polydatin, and bakuchiol. Results: The search yielded 18 phytoestrogens effective against heart disease.
Data were analyzed by STATA 16.0 software. The SYRCLE’s RoB tool was used to evaluate the quality. Then, we collected studies that met inclusion and exclusion criteria from January 2016 to September 2021. Methods: A systematic search was conducted to identify PEs that have been validated in animal studies or clinical studies as effective against MIRI. We aimed to investigate the effect of PE on MIRI and its intrinsic mechanisms. They have been identified to confer potent cardioprotective effects in experimental myocardial ischemia-reperfusion injury (MIRI) animal models.
3Department of Cardiovascular, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, Chinaīackground: Phytoestrogens are a class of natural compounds that have structural similarities to estrogens.2Department of Cardiovascular, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China.1Graduate School, Beijing University of Chinese Medicine, Beijing, China.Yumeng Wang 1,2 †, Xintian Shou 1,3 †, Zongjing Fan 2, Jie Cui 2, Donghua Xue 1,2 and Yang Wu 2*
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